FlexBuilder: the best UI framework for Unity3D
For more details, see the Detailed Features page.
Comparison with Unity built-in frameworks
UnityUI
Unity built-in
Unity's built-in UI system
Slow

Works with all AssetStore assets

Works with all existing scripts/code

Live-editing in-game/editor
FlexBuilder

Asset Store
The best of CSS3/Flexbox ... in Unity

Works with all AssetStore assets

Works with all existing scripts/code

Live-editing in-game/editor

Very fast to edit, very fast to refresh

FIXES: core Unity's text-rendering

FIXES: core Unity's slow UI

Implements almost 100% of the CSS3/Flexbox spec

Quick-building UI buttons
UIToolkit
Unity built-in
Experimental, 'not production ready'
Implements less than 90% of the CSS3/Flexbox spec
No live-editing
No integration with last 10 years of Unity UI scripts and assets
Slow to build/edit

Fast when not changing

Visual UI editor (buggy)